Keratin degradation by microorganisms is a safe and efficient alternative means of keratin wastes management and a process that produces products of high biotechnological value. Keratinolytic microorganisms convert keratin wastes into soluble proteins, peptides, and amino acids. The process is exclusively accompanied with the release of keratinases. Recently, research interest is rapidly growing on keratinases owing to their numerous present and promising applications in waste treatment, agro-industrial, pharmaceutical, and biomedical fields. Others include nanobiotechnology, leather, detergent, and cosmetic industries (Adelere and Lateef 2016a). Someof these biotechnological applications are briefly discussed.